Professeur Kim conducted a comparative analysis of the effects of 'RCI001' and '1% prednisolone (PDE steroid),' actuellement the most potent topical anti-inflammatoire agent in use, in an animal model of ocular chemical burn.
The research results revealed that 'RCI001' was superior in efficacy and had fewer effets secondaires compared to the existing steroid drug.
Specifically, 'RCI001' outperformed the steroid in épithélial cornéen defect and transparency recovery, infiltration of inflammatoire cells within corneal tissue, 'cytokines inflammatoires' that cause excessive inflammation on the ocular surface, and 'oxidative stress markers' indicating cell damage caused by reactive oxygen species in the body.
In contrast, élévation de la pression intraoculaire — a representative side effect commonly found with steroid drugs — was not observed with 'RCI001.'
Professeur Kim's research was published under the title 'Comparison of effets thérapeutiques between topical 8‑oxo‑2′‑deoxyguanosine and prednisolone in a rabbit model of acute ocular chemical injury,' drawing significatif attention from the academic community for providing a scientific basis for the potential of RCI001 as a next-generation ophtalmique treatment.