Purpose: To compare the 角膜上皮伤口愈合 effects of RCI001, Solcoseryl, and polydeoxyribonucleotide (PDRN) in a rat alkali burn model.
Methods: In 40 male Sprague-Dawley rats, we induced alkali burn using filter paper soaked in 0.2N sodium hydroxide. The rats were then treated with topical 0.5% RCI001, 1.0% RCI001, Solcoseryl, or PDRN twice a day for 2 weeks. 角膜 epithelial integrity and epithelial healing rate were measured at day 0, 3, 5, 7, 10, and 14. Histologic and immunohistochemistry findings were also assessed.
Results: Both the 0.5% and 1.0% RCI001 groups showed significantly more epithelial healing compared to the control group at day 5, 7, 10, and 14 (each p < 0.05). No statistical difference was found between the 0.5% and 1.0% RCI001 groups. Neither the Solcoseryl nor the PDRN groups showed a significant difference from the control. RCI001 treatment resulted in significantly reduced stromal edema, and a trend towards less inflammatory cell infiltration.
Conclusions: Topical application of RCI001 showed enhanced 角膜上皮伤口愈合 in the murine 角膜 alkali burn model, presumably by suppressing 炎症. Meanwhile, Solcoseryl and PDRN did not show sufficient therapeutic effects compared to RCI001.
Key Words: 角膜 epithelium, Polydeoxyribonucleotides, RCI001, Solcoseryl, Wound healing