CRO Services
Ion Channel Preclinical CRO
Specialized preclinical CRO evaluating chronic pain and dry eye disease candidates targeting TRPV1, TRPA1, and Nav ion channels. From electrophysiology-based cell assays to complex animal behavior studies, we cover the full preclinical drug development pipeline.
About
Tracing the Source of Pain Through Science
Neuropathic pain, osteoarthritis, chemotherapy-induced peripheral neuropathy, dry eye disease — the conditions we address all involve chronic pain and sensory disorders that disrupt daily life. With 19 years of expertise specialized in ion channel pharmacology, we precisely validate the efficacy of drug candidates.
Songdo Research Center
BRC 1-302, 9 Songdo Mirae-ro, Yeonsu-gu, Incheon
Seoul Research Center
Ace Hightower-3 #1001, 145 Gasandigital 1-ro, Geumcheon-gu, Seoul
Dr. Jiyoon Shin
Head of Central Research Laboratory
Core Services
Three Core CRO Services
From cellular screening to whole-animal studies — preclinical efficacy evaluation under one roof.
Drug Efficacy Evaluation
Precise pharmacological evaluation of therapeutic candidates in chronic pain, neurological, and dry eye disease animal models. We operate 5 pain types and 4 dry eye models.
In Vivo / In Vitro Evaluation
End-to-end execution: 7 drug administration routes including intrathecal, 4 blood sampling methods, neural tissue slide preparation, and 18-parameter hematological analysis.
FLIPR Penta Screening
High-throughput screening (HTS) using ion channel-expressing cell lines. Automatically measures calcium influx and membrane potential responses for thousands of compounds per day, including early-stage hERG cardiac safety evaluation.
Service 01 — Efficacy
Chronic Pain Models
Five distinct pain types — fully covered
Neuropathic Pain
Quantification of mechanical allodynia, cold hypersensitivity, and thermal hypersensitivity in peripheral nerve injury models (SNT, CCI, SNL). Threshold measurement with Von Frey filaments and thermal response time recording with the Plantar test.
Von Frey · Plantar test · Cold allodynia
Osteoarthritis Pain
Quantitative evaluation of spontaneous pain behavior and joint motor function changes in MIA (Monosodium iodoacetate)-induced OA models using weight-bearing asymmetry and gait analysis.
Weight-bearing · Gait analysis
Post-Surgical Pain
The Brennan plantar incision model reproduces acute and persistent post-surgical pain. Pain threshold changes are tracked from immediately after surgery through recovery.
Incisional pain model (Brennan)
Diabetic Peripheral Neuropathy
Quantification of peripheral sensory nerve hypersensitivity in STZ (Streptozotocin)-induced diabetic models. Blood glucose levels and pain thresholds are monitored simultaneously.
STZ-induced DPN model
Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Evaluation of chemical sensory abnormalities (cold allodynia) and mechanical allodynia in CIPN models treated with Paclitaxel, Oxaliplatin, and Cisplatin. Optimized model for novel drug projects targeting CIPN — the most common side effect of chemotherapy.
Paclitaxel · Oxaliplatin · Cisplatin
Service 02 — In Vivo / In Vitro
From Administration to Analysis
Full pipeline in-house — zero outsourcing
Drug Administration Routes (7)
- ·Intravenous (IV)
- ·Intraperitoneal (IP)
- ·Oral (PO)
- ·Subcutaneous (SC)
- ·Intramuscular (IM)
- ·Intradermal (ID)
- ·Intrathecal (IT)
Blood Sampling (4)
- ·Jugular vein
- ·Cardiac puncture
- ·Orbital sinus
- ·Aortic
Necropsy & Tissue
- ·Rodent neural tissue necropsy
- ·Tissue slide preparation
- ·DRG ganglion isolation
- ·Tissue fixation & embedding
Analysis Equipment
- ·Indiko hematology analyzer
- ·Biochemistry analysis
- ·Fluorescence microscopy
- ·Electrophysiology recording
Hematology Panel (18 parameters)
Disease Models
Disease Animal Models
Full coverage on Rat / Mouse platforms
Pain Models
- ·SNT (Spinal nerve transection)
- ·CCI (Chronic constriction injury)
- ·SNL (Spinal nerve ligation)
- ·CIPN (Paclitaxel / Oxaliplatin)
- ·DPN (STZ-induced)
- ·Post-surgical pain
- ·Osteoarthritis pain (MIA)
- ·Rheumatoid arthritis (RA)
- ·Inflammatory pain (CFA)
Eye / Other Models
- ·Environmental dry eye
- ·BAC-induced dry eye
- ·Alkali burn corneal injury
- ·Ethanol burn model
- ·LPS-induced pneumonia
- ·Gout model
- ·Ischemic model
- ·Stroke model
Cell / Neural-Based
- ·Human DRG neurons
- ·Rodent DRG neurons
- ·Rodent TG neurons
- ·Ion channel-overexpressing cell lines
- ·Acute brain & spinal cord slices
- ·Human iPSC cardiomyocytes
- ·Sprague-Dawley Rat
- ·C57BL/6 / ICR Mouse
Service 03 — HTS
FLIPR Penta Automated Screening
Thousands of compounds evaluated automatically per day
Ion Channel Efficacy Screening
HTS-based functional ion channel evaluation
- ·Human TRPV1 / Rat TRPV1
- ·Human TRPA1
- ·Human Nav1.4
- ·Human Nav1.7
- ·Human Nav1.8
- ·Calcium influx
- ·Calcium imaging
Cardiac Safety Screening
Early-stage cardiotoxicity evaluation
- ·hERG channel
- ·Cav1.2 channel
- ·Nav1.5 channel
- ·Human iPSC cardiomyocytes
- ·Cardiac safety panel
Assay Portfolio
One-stop measurement methodology
- ·Calcium assay (FURA-2 · FLUO-4)
- ·Potassium assay
- ·Luminescence Aequorin
- ·Membrane Potential dye
- ·GPCR assay
Track Record
Completed Contract Studies
Trusted by pharmaceutical companies and national research institutes
Pharmaceutical Contracts
- ▸Osteoarthritis pain mechanism research
- ▸Cold allodynia evaluation in neuropathic pain models
- ▸Action potential modulation efficacy of test substances
- ▸Reticulocyte count change measurement
- ▸Preclinical acute toxicity testing (Non-GLP)
- ▸Cytotoxicity testing
- ▸Pain ion channel antagonist screening
- ▸Pharmacokinetics & acute toxicity studies
- ▸Pneumonia model test substance viability analysis
- ▸Mechanism-based efficacy studies
Government R&D Contracts
- ▸BK channel relevance evaluation in vascular endothelial cells
- ▸Pain modulation efficacy in spinal neural circuits
- ▸TRPA1 ion channel functional inhibition evaluation
- ▸TRPV1 ion channel functional inhibition evaluation
- ▸Synaptic plasticity modulation under chemotherapy treatment
- ▸Discovery of key proteins regulating itch
- ▸Natural compound efficacy for diabetic neuropathy treatment
- ▸Ocular surface damage evaluation
- ▸Physicochemical property analysis
Global Partnership
Researching With the World
2026 · Jinshan, China
WuXi AppTec & RudaCure MOU
Strategic partnership signed with WuXi AppTec, the world's largest CDMO. Connected to global clinical development networks.
Contact
Let's Research Together
New contract studies, joint research, and service inquiries are all welcome. Start with RudaCure CRO.
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